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Anti -REDD-1/DDIT4 Rabbit pAb

货号:GB11937

品牌:Servicebio

价格:¥650

规格: 100 μl

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Product Information

 

 

Description

DDIT4 rabbit polyclonal

Protein full name

DNA damage-inducible transcript 4 protein

Synonyms

Ddit4, DDIT4, Dig2, REDD-1, REDD1, DNA damage inducible transcript 4

Immunogen

Recombinant protein corresponding to Mouse DDIT4

Isotype

IgG

Purity

Affinity purification

Subcellular location
 
Cytoplasm
 
Uniprot ID

Q9D3F7, Q8VHZ9 

 


 

Applications

 

 

Applications

IHC

IF
 
Species

Mouse, Rat

Mouse, Rat
Dilution

1: 1500-1: 3000

1: 500-1: 1500
 
Positive tissue pancreas, testis pancreas, testis
 

 


 

Background

 

DNA-damage-inducible transcript 4 (DDIT4) protein is a protein encoded by the DDIT4 gene. DDIT4 acts as a negative regulator of mTOR, a serine/threonine kinase that regulates a variety of cellular functions such as growth, proliferation and autophagy. In particular, upregulation of HIF-1 in response to hypoxia upregulates DDIT4, leading to activation of Tsc1/2 via 14–3–3 shuttling and subsequent downregulation of mTOR via Rheb. In addition to hypoxia, DDIT4 expression has also been shown to be activated by DNA damage and energy stress.

            


 

Images

 

 

Immunohistochemistry analysis of paraffin-embedded mouse pancreas using DDIT4 (GB11937) at dilution of 1: 1500

   

Immunohistochemistry analysis of paraffin-embedded rat pancreas using
DDIT4 (GB11937) at dilution of 1: 1500

 
   

Immunohistochemistry analysis of paraffin-embedded rat testis using
DDIT4 (GB11937) at dilution of 1: 1500

 

 


 

Storage

 

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.

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