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Anti -Tollip Rabbit pAb

货号:GB111093

品牌:Servicebio

价格:¥650

规格: 100μl

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Product Information

 

Description

Tollip rabbit polyclonal

Protein full name  Toll-interacting protein
 

Synonyms

TOLLIP, IL-1RAcPIP, toll interacting protein

Immunogen

Recombinant protein corresponding to Mouse Tollip

Isotype IgG
Purity Affinity purification
Subcellular location
 
Cytoplasm
 

Predicted MW.

30 kDa

Observed MW.

30 kDa

Uniprot ID

Q9H0E2, Q9QZ06

 


 

Applications

 

Applications

WB

IHC
 
IF
 
Species

Mouse, Rat

Human, Mouse, Rat
 
Human, Mouse, Rat
 
Dilution

1: 500-1: 1000

1: 1000-1: 2000
 
1: 500-1: 1000
 
Positive tissue

brain, spleen, thymus

liver cancer, spleen, brain, kidney, lung
 
liver cancer, spleen, brain, kidney, lung
 

 


 

Background

 

The Tollip is the component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates
 


 

Images

 

Western blot analysis of NCR1 (GB111102) at dilution of 1: 1000
Lane 1: Mouse brain tissue lysate
Lane 2: Mouse spleen tissue lysate
Lane 3: Mouse thymus tissue lysate
Lane 4: Mouse brain tissue lysate
Lane 5: Mouse spleen tissue lysate
Lane 6: Mouse thymus tissue lysate
 

   

Immunohistochemistry analysis of paraffin-embedded human liver cancer using Tollip (GB111093) at dilution of 1: 2000
 
   

Immunohistochemistry analysis of paraffin-embedded mouse spleen using Tollip (GB111093) at dilution of 1: 2000
 
   

Immunohistochemistry analysis of paraffin-embedded rat kidney using Tollip (GB111093) at dilution of 1: 2000
 
   

Immunohistochemistry analysis of paraffin-embedded rat brain using Tollip (GB111093) at dilution of 1: 2000
 
   

Immunohistochemistry analysis of paraffin-embedded rat lung using Tollip (GB111093) at dilution of 1: 2000
 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.

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