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Anti -NCR1 Rabbit pAb

货号:GB111102

品牌:Servicebio

价格:¥650

规格: 100μl

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Product Information

 

Description

NCR1 rabbit polyclonal

Protein full name
Natural cytotoxicity triggering receptor 1

Synonyms

Activating receptor 1, mAR-1, Lymphocyte antigen 94, Natural killer cell p46-related protein, NK-p46, NKp46, CD335, Ncr1, Ly94

Immunogen

Recombinant protein corresponding to Mouse NCR1

Isotype IgG
Purity Affinity purification
Predicted MW.
 
37 kDa
 
Observed MW.
 
46 kDa
 
Uniprot ID

Q8C567, Q9Z0H5

 


 

Applications

 

Applications

WB

Species

Mouse, Rat

Dilution

1: 500-1: 1000

Positive tissue

spleen, thymus, lymph gland

 


 

Background

 

NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR) . These receptors are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. Mouse NKp46, also known as MAR-1, is a type I transmembrane protein with two extracellular Ig-like domains. It has a positive charge in its transmembrane domain that permits association with the ITAM-bearing signal adapter proteins, CD3 zeta and Fc epsilon RI gamma. Studies with neutralizing antibodies indicate that the three NCR are primarily responsible for triggering the NK-mediated lysis of many human tumor cell lines. Blocking any of the NCRs individually resulted in partial inhibition of tumor cell lysis, but nearly complete inhibition of lysis was observed if all three receptors were blocked simultaneously. NKp46 has also been implicated in recognition of virus-infected cells through its capacity to bind to viral hemagglutinins.
 


 

Images

 

IWestern blot analysis of NCR1 (GB111102) at dilution of 1: 1000
Lane 1: A549 cell lysate
Lane 2: RAW264.7 cell lysate
Lane 3: Jurkat cell lysate
Lane 4: Mouse spleen tissue lysate
Lane 5: Mouse thymus tissue lysate
Lane 6: Mouse lymph gland tissue lysate
Lane 7: Rat spleen tissue lysate
Lane 8: Rat thymus tissue lysate
Lane 9: Rat lymph gland tissue lysate
 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.

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