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Anti -Pin1 Rabbit pAb

货号:GB111193

品牌:Servicebio

价格:¥650

规格: 100μl

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Product Information

 

Description

Pin1 rabbit polyclonal

Protein full name
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Synonyms

Peptidyl-prolyl cis-trans isomerase Pin1, PPIase Pin1

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse Pin1

Isotype IgG
Purity Affinity purification

Predicted MW.

18 kDa

Observed MW.

18 kDa

Uniprot ID

Q13526, Q9QUR7, B0BNL2

 


 

Applications

 

Applications

WB

Species

Human, Mouse, Rat

Dilution

1: 300-1: 800

Positive tissue

spleen, testis

 


 

Background

 

Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds.Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration.
 


 

Images

 

Western blot analysis of Pin1 (GB111193) at dilution of 1: 800
Lane 1: Raji cell lysate
Lane 2: Hela cell lysate
Lane 3: Mouse spleen tissue lysate
Lane 4: Mouse testis tissue lysate
Lane 5: Rat spleen tissue lysate
Lane 6: Rat testis tissue lysate
 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.

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